Then, co‐localized lung‐wide datasets of both cyto‐architectures and fluorescent particles are collected at full scale with the resolution down to individual particles. Here, taking advantage of the micro optical sectioning tomography system, the high‐precision cross‐scale visualization of entire lung anatomy is obtained. Revealing the sophisticated lung scaffold and intrapulmonary distribution of particles at three‐dimensional (3D), in‐situ, and single‐particle level remains a fundamental and critical challenge for dry powder inhalation in pre‐clinical research. The effective pulmonary deposition of inhaled particulate carriers loaded with drugs is a prerequisite for therapeutic effects of drug delivery via inhalation route.
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